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ILLINOIS STATE UNIVERSITY

Watch now: ISU lab explores flies and autoimmune disorders

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Illinois State University biology professor Nathan Mortimer speaks about how a recent paper and research from his lab could someday be used to describe autoimmune disorders in humans. READ MORE HERE.

NORMAL — A common household pest could explain how autoimmune disorders occur in humans. A recent paper by an Illinois State University professor and past and present students helps describe how fruit flies' immune systems avoid attacking their own tissue. 

The study found that the cells responding to a potential infection identify which tissue to not attack by the layer of proteins with specific sugars surrounding cells. 

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At least some autoimmune disorders may be related to problems identifying or producing those types sugars.  

There are two types of immune responses, said ISU biology professor Nathan Mortimer. People have become more familiar with acquired immunity during the COVID-19 pandemic, as is is what vaccines use. 

Nathan Mortimer explains fly research

Nathan Mortimer, a biology professor at Illinois State University, explains some of the research his lab has done on immune responses in fruit flies on Wednesday outside his lab in the Science Laboratory Building. 

Mortimer’s study focuses on innate immunity, which is more general responses like inflammation. So far, innate immunity has not been studied as much as acquired immunity, he said.

“The work that has been done shows innate immunity is really important for autoimmune disorders,” he said.

Flies are perfect for studying innate immunity because they do not have acquired immunity, Mortimer said. 

Mortimer is the lead author on a study published Sept. 28 in "Proceedings of the National Academy of Sciences." Joining him as co-authors were nine other people from the ISU biology department and biologists from the University of Pennsylvania, Stanford University, University of Arizona and Emory University.

Many of the co-authors are past or current students, both graduate and undergraduate. Mortimer wants to make sure students can get involved in actually doing science early on in their university career.

“(It’s about) getting students involved in the research as early as possible and as often as possible,” he said.

One way he does that is through teaching classes that involve designing and performing research. Course-based Undergraduate Research Experience (CURE) courses are a growing trend in academia, he said.

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Ashley Waring first got involved with the topic of fruit flies and immune responses during a CURE class called Biotech II. She has worked in Mortimer's lab as a undergraduate, for her master's degree and now as a PhD candidate.

“Not every undergrad can volunteer or work in a research lab, so having courses that are research-based makes gaining that research experience more equitable for all undergrads,” she said.

Waring is excited to see the growth of the project over the five years since she was in Biotech II. She has been able to see the research progress through the work done by undergrads and graduate students.

Nathan Mortimer in his lab

Illinois State University biology professor Nathan Mortimer shows some off some of the flies used for research in his lab in the Science Laboratory Building on Wednesday. 

Along with making sure students can participate in research, Mortimer also wants to make sure students build a solid foundation for future research. Being a science student should not just be learning about science, but students should also learn how to be scientists, he said. That sometimes means slowing down and really working on the basic skills needed.

“People are in a rush to ‘do the thing,’ and then forget that ‘the thing’ involves a lot of little skills,” Mortimer said.

The fruit fly research can be as easy as counting which fly larvae look different from the other ones.

One of the immune responses in the flies is the production of melanin in immune response cells which surround parasites. Students can literally count how many fly larvae show dark masses in their bodies. 

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That research focuses on the interaction between the fruit flies and parasitoid wasps. That was what got Waring interested at first, and is still her main field of study.

The article in PNAS focused on a more specific part of the flies’ immune response. An essential part of an innate immunity is an ability to differentiate foreign tissue from the fly’s own tissue. The study started to identify the mechanisms used to do that, Mortimer said.

Fruit flies are a valuable research organism because their genome remains around 70% similar to humans while also being much simpler, Mortimer said.

The sugars are a sort of central point, he said. Now the research needs to explore how the immune cells identify the sugars and how those sugars are produced. Further down the road, Mortimer would like to see collaboration with medical researchers on potential human applications.

“That’s where I would love this to go eventually,” he said.

Contact Connor Wood at (309)820-3240. Follow Connor on Twitter: @connorkwood

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